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Risks of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant use of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may bring about a rise in tramadol plasma ranges as well as a reduce in the amounts of the active metabolite, M1.Healthdirect Australia is just not